Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332757 | 0.80 | SMN1; SMN2 (0.54) | KDM4EPOLBPARP1ARGAA | |
| SCHEMBL13365569 | 0.78 | LMNA (0.67) | GAAHTTMEN1MAPTKMT2A | |
| SCHEMBL5019074 | 0.76 | LMNA (0.73) | GAAHTTALDH1A1MEN1MAPT | |
| SCHEMBL17444767 | 0.76 | KDM4E (0.73) | KDM4EPOLBPARP1ARGAA | |
| Hydrochloric Acid SCHEMBL4506331 | 0.75 | LMNA (0.71) | GAAHTTALDH1A1MEN1MAPT | |
| SCHEMBL6326092 | 0.74 | MAPT (0.61) | KDM4EPOLBPARP1ARGAA | |
| SCHEMBL13055383 | 0.74 | LMNA (0.80) | GAAHTTALDH1A1MEN1MAPT | |
| SCHEMBL13858810 | 0.74 | KDM4E (0.66) | KDM4EPOLBPARP1ARGAA | |
| SCHEMBL7364819 | 0.71 | LMNA (0.65) | GAAHTTALDH1A1MEN1MAPT | |
| SCHEMBL11376465 | 0.71 | HTT (0.70) | HTTALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |