Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 10/20 | 0.48 |
| ▸ | GAA | P10253 | 10/20 | 0.48 |
| ▸ | SI | P14410 | 10/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 10/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATP4A | P20648 | 1/20 | 0.45 |
| ▸ | ATP4B | P51164 | 1/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727228 | 0.90 | MGAM (0.53) | ALDH1A1MGAMGAASIMGAM2 | |
| SCHEMBL3137529 | 0.79 | HRH4 (0.58) | ALDH1A1TDP1PARP1HPSEMGAM | |
| Carbamic Acid SCHEMBL6315736 | 0.77 | RPS6KA3 (0.51) | PARP1NUDT1 | |
| SCHEMBL6842051 | 0.77 | PARP1 (0.69) | PARP1 | |
| SCHEMBL1144691 | 0.77 | HRH4 (0.59) | ALDH1A1TDP1HPSEMGAMGAA | |
| SCHEMBL8260543 | 0.77 | KDM4E (0.60) | PARP1KDM4EHPGD | |
| SCHEMBL1193115 | 0.75 | PARP1 (0.54) | PARP1KDM4EHPGDNUDT1 | |
| SCHEMBL3420273 | 0.75 | PARP1 (0.50) | ALDH1A1TDP1PARP1HPSEMGAM | |
| Carbamic Acid SCHEMBL6323888 | 0.74 | TYMS (0.44) | ALDH1A1PARP1GAAKDM4ENUDT1 | |
| SCHEMBL3413861 | 0.74 | HPSE (0.55) | ALDH1A1TDP1HPSEMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288348-A1 | Compounds and methods for use thereof in the treatment of cancer | UAF TECHNOLOGIES AND RESEARCH, LLC (US) | 2005-12-29 | — | — | US | disclosed |
| US-6930121-B2 | Compounds and methods for use thereof in the treatment of viral infections | UAF TECHNOLOGIES AND RESEARCH, LLC (US) | 2005-08-16 | — | — | US | disclosed |
| US-6916836-B2 | Compounds and methods for use thereof in the treatment of viral infections | UAF TECHNOLOGIES AND RESEARCH, LLC (US) | 2005-07-12 | — | — | US | disclosed |
| US-6720349-B2 | BENZIMIDAZOLE DERIVATIVES AND SALTS AND PRODRUGS THEREOF | UAF TECHNOLOGIES AND RESEARCH, LLC | 2004-04-13 | — | — | US | disclosed |
| US-20040029942-A1 | Compounds and methods for use thereof in the treatment of viral infections | UNIVERSITY OF ARIZONA FOUNDATION | 2004-02-12 | — | — | US | disclosed |
| US-6608096-B1 | 2-N-alkylurea Benzimidazole derivatives | UNIVERSITY OF ARIZONA FOUNDATION | 2003-08-19 | — | — | US | disclosed |
| EP-1330441-A2 | BENZIMIDAZOLES AND METHODS FOR USE THEREOF IN THE TREATMENT OF CANCER OR VIRAL INFECTIONS | The University of Arizona Foundation (US) | 2003-07-30 | — | — | EP | disclosed |
| US-20030100592-A1 | Compounds and methods for use thereof in the treatment of viral infections | UNIVERSITY OF ARIZONA FOUNDATION (US) | 2003-05-29 | — | — | US | disclosed |
| US-20020193609-A1 | Compounds and methods for use thereof in the treatment of cancer or viral infections | THE PROCTER & GAMBLE COMPANY | 2002-12-19 | — | — | US | disclosed |
| US-6462062-B1 | N-ESTER OR AMIDE SUBSTITUTED 2-AMINO-BENZIMIDAZOLES | THE PROCTER & GAMBLE COMPANY | 2002-10-08 | — | — | US | disclosed |
| US-6407105-B1 | 2-AMINO-1-CARBOXYBENZIMIDAZOLE DERIVATIVES; VIRICIDES, ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | THE PROCTER & GAMBLE COMPANY | 2002-06-18 | — | — | US | disclosed |
| US-6380232-B1 | FOR THERAPY OF CANCER OR A VIRAL INFECTION IN WARM BLOODED ANIMALS, MAY BE USED IN COMBINATION WITH POTENTIATOR OR OTHER DRUG | THE PROCTER & GAMBLE COMPANY | 2002-04-30 | — | — | US | disclosed |
| WO-2002026716-A2 | BENZIMIDAZOLES AND METHODS FOR USE THEREOF IN THE TREATMENT OF CANCER OR VIRAL INFECTIONS | THE PROCTER & GAMBLE COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100592-A1 | Compounds and methods for use thereof in the treatment of viral infections | PAICS, PIGO, BAD | ALDH1A1 260/4885TDP1 1614/4885PARP1 1133/4885 |
| US-20040029942-A1 | Compounds and methods for use thereof in the treatment of viral infections | PAICS, PIGO, BAD | ALDH1A1 260/4885TDP1 1614/4885PARP1 1133/4885 |
| US-20050288348-A1 | Compounds and methods for use thereof in the treatment of cancer | PAICS, BAD, PIGO | ALDH1A1 127/4885TDP1 1431/4885PARP1 1039/4885 |
| US-20020193609-A1 | Compounds and methods for use thereof in the treatment of cancer or viral infections | PAICS, MCL1, BAD | ALDH1A1 204/4885TDP1 1408/4885PARP1 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.