Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL1500439 | 1.00 | CA2 (0.42) | CA2SLC34A1KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL8672238 | 1.00 | CA2 (0.42) | CA2SLC34A1KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL15270536 | 1.00 | CA2 (0.42) | CA2SLC34A1KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL29694 | 1.00 | CA2 (0.42) | CA2SLC34A1KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL19128084 | 0.95 | CA2 (0.39) | CA2SLC34A1KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL28492485 | 0.91 | CA2 (0.36) | CA2SLC34A1KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL28497623 | 0.87 | CA2 (0.33) | CA2SLC34A1FDPS | |
| Phosphoric Acid SCHEMBL11050140 | 0.82 | — | — | |
| Phosphoric Acid SCHEMBL21635219 | 0.82 | — | — | |
| Phosphoric Acid SCHEMBL5907 | 0.82 | CA2 (0.56) | CA2SLC34A1KDM4EMMP2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107236735-B | The inhibitor based on oligonucleotides comprising lock nucleic acid motif | 米拉根医疗股份有限公司 | 2019-11-08 | — | — | CN | disclosed |
| CN-105188715-B | Locked nucleic acid inhibitor of MIR-145 and application thereof | 米拉根医疗股份有限公司 | 2018-12-25 | — | — | CN | disclosed |
| CN-107636003-A | Inhibitor of miR 92 and application thereof | 米拉根医疗股份有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-107236735-A | The inhibitor based on oligonucleotides comprising lock nucleic acid motif | 米拉根医疗股份有限公司 | 2017-10-10 | — | — | CN | disclosed |
| US-6906185-B1 | Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof | AMERSHAM BIOSCIENCES CORP. (US) | 2005-06-14 | — | — | US | disclosed |
| EP-0866070-A1 | Derivatives of 7 deaza 2' deoxy guanosine 5' triphosphate, preparation and use thereof | Amersham Pharmacia Biotech Inc (US) | 1998-09-23 | — | — | EP | disclosed |