Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | MARS1 | P56192 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13330470 | 0.91 | MEN1 (0.49) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL8436952 | 0.82 | CHRM2 (0.53) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL25471395 | 0.80 | HTR2A (0.47) | MEN1KMT2AKDM4ETSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8432474 | 0.80 | MEN1 (0.51) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| Formic Acid SCHEMBL5072954 | 0.79 | MEN1 (0.49) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL12963417 | 0.76 | MEN1 (0.51) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL9832247 | 0.75 | SMN1; SMN2 (0.50) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL10384415 | 0.75 | CHRM2 (0.73) | MEN1KMT2AHDAC1KDM4ESMN1; SMN2 | |
| SCHEMBL3544426 | 0.74 | KMT2A (0.51) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| Formic Acid SCHEMBL6325278 | 0.74 | KDM4E (0.58) | MEN1KMT2AKDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |