Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072062 | 0.90 | MAPT (0.44) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6328370 | 0.90 | KMT2A (0.48) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6326079 | 0.84 | HCAR2 (0.41) | ALDH1A1KMT2ATSHRMEN1MAPT | |
| SCHEMBL6327904 | 0.83 | HPGD (0.59) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6332801 | 0.82 | HPGD (0.53) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6324028 | 0.81 | HPGD (0.59) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6328158 | 0.80 | HPGD (0.53) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6325765 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6327874 | 0.79 | AURKB (0.50) | KMT2ARAB9APOLBAURKBPARP1 | |
| SCHEMBL6323211 | 0.79 | CYP1A2 (0.60) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |
| US-20040087588-A1 | Parp inhibitors | ICOS CORPORATION | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087588-A1 | Parp inhibitors | PARP1, PARP2, PARP11 | ALDH1A1 338/4885KMT2A 152/4885SMN1; SMN2 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.