Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324564 | 0.90 | ALDH1A1 (0.49) | KMT2AMAPTHDAC1HDAC8ALDH1A1 | |
| SCHEMBL5072062 | 0.88 | MAPT (0.44) | KMT2AMAPTHPGDGAAALDH1A1 | |
| SCHEMBL6333150 | 0.86 | TP53 (0.50) | MAPTHDAC1HPGDGAAALDH1A1 | |
| SCHEMBL6328207 | 0.84 | GAA (0.53) | KMT2AMAPTHDAC1HPGDGAA | |
| SCHEMBL6328474 | 0.83 | GAA (0.57) | MAPTHPGDGAAALDH1A1TP53 | |
| SCHEMBL6332336 | 0.82 | GAA (0.53) | KMT2AMAPTHDAC1HPGDGAA | |
| SCHEMBL6323935 | 0.81 | MAPT (0.52) | MAPTHDAC1HPGDGAAALDH1A1 | |
| SCHEMBL6323563 | 0.81 | TSHR (0.57) | KMT2AMAPTHPGDGAAALDH1A1 | |
| SCHEMBL6326079 | 0.80 | HCAR2 (0.41) | KMT2AMAPTHDAC1HDAC8GAA | |
| SCHEMBL6323802 | 0.77 | HPGD (0.52) | KMT2AMAPTHPGDGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |