Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SPAST | Q9UBP0 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 4/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786527 | 1.00 | HTR2C (0.43) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL5804701 | 1.00 | HTR2C (0.43) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL5805354 | 0.90 | HTR2C (0.46) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL6329138 | 0.90 | HTR2C (0.46) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL5785292 | 0.90 | HTR2C (0.46) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL5787896 | 0.89 | SPAST (0.47) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL6327493 | 0.89 | SPAST (0.47) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL6328772 | 0.89 | SPAST (0.47) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL6329189 | 0.88 | HTR2C (0.42) | HTR2CHTR2BCYP1A2CYP3A4SPAST | |
| SCHEMBL5785386 | 0.88 | HTR2C (0.42) | HTR2CHTR2BCYP1A2CYP3A4SPAST |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | WARNER-LAMBERT COMPANY LLC | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | SLC6A2, SLC18A2, SLC6A3 | HTR2C 36/4885HTR2B 51/4885CYP1A2 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.