Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | SCN4A | P35499 | 2/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2258014 | 0.87 | CLK4 (0.52) | CLK4MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL18487218 | 0.85 | KMT2A (0.50) | CLK4MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL7014701 | 0.83 | CLK4 (0.61) | CLK4SCN4ANPC1RAB9AADRB2 | |
| SCHEMBL13270537 | 0.82 | SCN4A (0.46) | CLK4SCN4ASCN9AMEN1KMT2A | |
| SCHEMBL6329713 | 0.79 | CYP1A2 (0.54) | SCN4ASCN9AL3MBTL1MAPTLMNA | |
| SCHEMBL3134648 | 0.79 | SCN9A (0.52) | CLK4SCN4ASCN9AMEN1KMT2A | |
| SCHEMBL21882442 | 0.78 | CLK4 (0.55) | CLK4SCN4AMEN1KMT2AL3MBTL1 | |
| SCHEMBL6943230 | 0.77 | MEN1 (0.63) | SCN4ASCN9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL27945412 | 0.75 | MKNK1 (0.50) | CLK4SCN4ASCN9AMEN1KMT2A | |
| SCHEMBL22044459 | 0.75 | NPC1 (0.46) | CLK4MEN1KMT2AL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867210-B2 | Aryl substituted pyrimidines | EURO-CELTIQUE S.A. (LU) | 2005-03-15 | — | — | US | disclosed |
| US-20050043305-A1 | Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof | EURO-CELTIQUE S.A. (LU) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043305-A1 | Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof | CACNA1S, CACNA1C, KYNU | CLK4 2058/4885SCN4A 88/4885SCN9A 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.