Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CYP2J2 | P51589 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL6329155 | 0.89 | HRH1 (0.55) | HRH1KCNH2LMNADRD3HTR2A | |
| Methane SCHEMBL6332223 | 0.87 | HRH1 (0.66) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL11401175 | 0.84 | KCNH2 (0.57) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL11369936 | 0.84 | HRH1 (0.60) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL6327145 | 0.80 | KCNH2 (0.52) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL2456709 | 0.80 | HRH1 (0.74) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL11377990 | 0.79 | HRH1 (0.72) | HRH1KCNH2LMNADRD3HTR2A | |
| Methane SCHEMBL6327614 | 0.79 | CYP2J2 (0.75) | HRH1KCNH2CYP2J2CYP3A4CYP2C9 | |
| SCHEMBL6329151 | 0.79 | HRH1 (0.62) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL1971496 | 0.78 | KCNH2 (0.55) | HRH1KCNH2LMNADRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | LING KAH HIING (US) | 2003-04-03 | — | — | US | disclosed |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | LING KAH HIING (US) | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | HRH4, HRH2, HRH1 | HRH1 3/4885KCNH2 553/4885LMNA 4739/4885 |
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | HRH1 3/4885KCNH2 443/4885LMNA 4788/4885 |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | HRH4, HRH2, HRH1 | HRH1 3/4885KCNH2 348/4885LMNA 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.