Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 8/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419515 | 0.85 | SCN9A (0.36) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| SCHEMBL4566138 | 0.85 | SCN9A (0.36) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| SCHEMBL2646342 | 0.85 | SCN9A (0.36) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| SCHEMBL248747 | 0.84 | NOS2 (0.39) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| SCHEMBL248746 | 0.84 | NOS2 (0.39) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| SCHEMBL40093 | 0.84 | NOS2 (0.39) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| SCHEMBL20492529 | 0.84 | SCN9A (0.35) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| Hydrochloric Acid SCHEMBL661790 | 0.83 | NOS2 (0.38) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| Hydrochloric Acid SCHEMBL596114 | 0.83 | NOS2 (0.38) | SCN9ASCN3ASCN5ADPP4DPP8 | |
| Hydrochloric Acid SCHEMBL661789 | 0.83 | NOS2 (0.38) | SCN9ASCN3ASCN5ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2093228-B1 | PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2012-02-22 | — | — | EP | disclosed |
| US-20100152240-A1 | PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | ZHANG HESHENG | 2010-06-17 | — | — | US | disclosed |
| EP-2093228-A1 | PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tianjin Hemey Bio-Tech Co., Ltd. (CN) | 2009-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152240-A1 | PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TNF, IL1B, CYC1 | SCN9A 2351/4885SCN3A 1076/4885SCN5A 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.