Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28548849 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2HSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL6325005 | 0.73 | MAPT (0.44) | HSD17B10ALDH1A1LMNAMAPTHTT | |
| SCHEMBL20863084 | 0.64 | HRH2 (0.47) | ALDH1A1MAPTADH1BADH1CADH1A | |
| SCHEMBL2473572 | 0.63 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL4846815 | 0.62 | NAAA (0.46) | FUCA1 | |
| SCHEMBL4846105 | 0.62 | NAAA (0.46) | FUCA1 | |
| SCHEMBL5079092 | 0.62 | — | — | |
| Hydrochloric Acid SCHEMBL4854553 | 0.61 | NAAA (0.45) | FUCA1 | |
| SCHEMBL11971687 | 0.61 | FYN (0.41) | ALDH1A1LMNAHTTKDM1AGRIN2B | |
| SCHEMBL21518380 | 0.61 | GRIN2B (0.38) | HSD17B10ALDH1A1ADH1BADH1CADH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005026141-A2 | PROCESS FOR PREPARATION OF SUBSTITUTED BUTENOLIDES VIA PALLADIUM-FREE ETHERIFICATION AND AMINATION OF MASKED MUCOHALIC ACIDS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | claimed |
| US-20050059831-A1 | Preparation of substituted butenolides via palladium-free etherification and amination of masked mucohalic acids | BLAZECKA PETER GARTH (CA) | 2005-03-17 | — | — | US | claimed |
| WO-2005026141-A2 | PROCESS FOR PREPARATION OF SUBSTITUTED BUTENOLIDES VIA PALLADIUM-FREE ETHERIFICATION AND AMINATION OF MASKED MUCOHALIC ACIDS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050059831-A1 | Preparation of substituted butenolides via palladium-free etherification and amination of masked mucohalic acids | BLAZECKA PETER GARTH (CA) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059831-A1 | Preparation of substituted butenolides via palladium-free etherification and amination of masked mucohalic acids | DBH, OR51E2, OR10J3 | SMN1; SMN2 3078/4885HSD17B10 1336/4885ALDH1A1 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.