Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326788 | 0.84 | KMT2A (0.35) | TAS1R3TAS1R1PPARGPPARALMNA | |
| SCHEMBL6325580 | 0.81 | TAS1R3 (0.44) | SMN1; SMN2TDP1TAS1R3TAS1R1 | |
| SCHEMBL12890020 | 0.71 | SMN1; SMN2 (0.61) | SMN1; SMN2TDP1MEN1KMT2ANPC1 | |
| SCHEMBL5075721 | 0.67 | DRD2 (0.59) | SMN1; SMN2LMNAGAAMAPTMEN1 | |
| SCHEMBL5073490 | 0.66 | DRD2 (0.61) | SMN1; SMN2LMNAGAAMAPTMEN1 | |
| SCHEMBL20324712 | 0.65 | ESR1 (0.40) | SMN1; SMN2TAS1R3TAS1R1PPARGPPARA | |
| SCHEMBL16976332 | 0.65 | RHEB (0.36) | SMN1; SMN2PPARGPPARAGAAL3MBTL1 | |
| SCHEMBL13245939 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2TDP1TAS1R3TAS1R1PPARG | |
| SCHEMBL3991808 | 0.65 | PPARG (0.52) | SMN1; SMN2PPARGPPARAMAPTMEN1 | |
| Formic Acid SCHEMBL5073487 | 0.64 | DRD2 (0.55) | SMN1; SMN2TDP1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |