Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321587 | 1.00 | ADORA2A (0.45) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL6319299 | 0.87 | ADORA2A (0.42) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL6319293 | 0.87 | ADORA2A (0.42) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL6328264 | 0.84 | ADORA2A (0.57) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL6328271 | 0.84 | ADORA2A (0.57) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL6345883 | 0.84 | ADORA2A (0.57) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL6345875 | 0.84 | ADORA2A (0.57) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL5052460 | 0.82 | RXFP1 (0.53) | ADORA3NT5E | |
| SCHEMBL5052456 | 0.82 | RXFP1 (0.53) | ADORA3NT5E | |
| SCHEMBL5062668 | 0.81 | RXFP1 (0.44) | ADORA2AADORA3ADORA1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124574-A1 | Purine derivatives | PFIZER INC. | 2005-06-09 | — | — | US | disclosed |
| US-6900309-B1 | Purine derivatives | PFIZER INC (US) | 2005-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124574-A1 | Purine derivatives | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.