Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11566842 | 0.79 | GAA (0.51) | GAAALDH1A1MAPTPTGDR2SMN1; SMN2 | |
| SCHEMBL16586316 | 0.77 | GAA (0.63) | GAAALDH1A1MAPTPTGDR2SMN1; SMN2 | |
| SCHEMBL16047133 | 0.76 | ALDH1A1 (0.61) | GAAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3618698 | 0.74 | KMT2A (0.56) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3537226 | 0.74 | PTGDR2 (0.56) | ALDH1A1PTGDR2SMN1; SMN2HPGDPOLB | |
| SCHEMBL14184594 | 0.73 | MEN1 (0.69) | GAAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL21313797 | 0.73 | RAB9A (0.78) | GAAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL17324735 | 0.73 | SMN1; SMN2 (0.76) | GAAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4765972 | 0.71 | NPC1 (0.76) | GAAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4400357 | 0.71 | RAB9A (0.86) | GAAALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958350-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-25 | — | — | US | disclosed |
| EP-1363902-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-15 | — | — | EP | disclosed |
| US-20040102483-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | US | disclosed |
| EP-1363902-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002066460-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102483-A1 | Chemical compounds | CXCR1, CXCR2, CXCR4 | GAA 3524/4885ALDH1A1 684/4885MAPT 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.