Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334127 | 0.73 | CYP1A2 (0.52) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL6328504 | 0.73 | HCRTR1 (0.46) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL5077241 | 0.72 | GAA (0.50) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL6326412 | 0.72 | TSHR (0.51) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL6326111 | 0.72 | TSHR (0.51) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL6333059 | 0.70 | SMN1; SMN2 (0.47) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL6325850 | 0.70 | HDAC1 (0.51) | CNR2HPGDALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL6332518 | 0.70 | HDAC1 (0.51) | CNR2HPGDALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL6323086 | 0.69 | HPGD (0.49) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6334365 | 0.68 | HDAC1 (0.48) | CNR2HPGDALDH1A1SMN1; SMN2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |