Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.54 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.53 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | TDP2 | O95551 | 2/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.46 |
| ▸ | CDK1 | P06493 | 6/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.46 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16090379 | 0.90 | BRD4 (0.52) | BRD4CREBBPPIP4K2APIP4K2BABL1 | |
| SCHEMBL5843496 | 0.90 | JAK2 (0.51) | BRD4CREBBPPIP4K2APIP4K2BABL1 | |
| SCHEMBL6323945 | 0.84 | JAK2 (0.49) | BRD4CREBBPPIP4K2APIP4K2BABL1 | |
| SCHEMBL155873 | 0.83 | GSK3B (0.50) | BRD4CREBBPPIP4K2APIP4K2BABL1 | |
| SCHEMBL6321593 | 0.83 | TDP2 (0.52) | PIP4K2APIP4K2BABL1TDP2AHR | |
| SCHEMBL10712645 | 0.83 | TDP2 (0.52) | PIP4K2APIP4K2BABL1TDP2GRIA1 | |
| SCHEMBL6319680 | 0.83 | PGR (0.58) | PIP4K2APIP4K2BABL1TDP2AHR | |
| SCHEMBL6320773 | 0.82 | TDP2 (0.55) | BRD4CREBBPPIP4K2APIP4K2BABL1 | |
| SCHEMBL6320969 | 0.80 | GSK3B (0.53) | PIP4K2APIP4K2BABL1TDP2CCNB2 | |
| SCHEMBL6321744 | 0.80 | JAK2 (0.55) | BRD4CREBBPPIP4K2APIP4K2BABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | BRD4 180/4885CREBBP 174/4885PIP4K2A 373/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | BRD4 180/4885CREBBP 174/4885PIP4K2A 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.