Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 15/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 13/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.64 |
| ▸ | ATP4A | P20648 | 2/20 | 0.48 |
| ▸ | ATP4B | P51164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326245 | 0.93 | ADRB3 (0.65) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6326745 | 0.93 | ADRB3 (0.65) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6331091 | 0.92 | ADRB3 (0.77) | ADRB3ADRB1ADRB2 | |
| SCHEMBL6333552 | 0.92 | ADRB3 (0.76) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6327671 | 0.92 | ADRB3 (0.76) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6330751 | 0.91 | ADRB3 (0.75) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6329497 | 0.89 | ADRB3 (0.65) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6327667 | 0.89 | ADRB3 (0.68) | ADRB3ADRB1ADRB2 | |
| SCHEMBL6336046 | 0.87 | ADRB3 (0.73) | ADRB3ADRB1ADRB2ATP4AATP4B | |
| SCHEMBL6331125 | 0.87 | ADRB3 (0.57) | ADRB3ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075323-A1 | Beta3 adrenergic receptor agonists and uses thereof | PFIZER INC | 2005-04-07 | — | — | US | disclosed |
| US-6706743-B2 | β3 adrenergic receptor agonists and uses thereof | PFIZER INC | 2004-03-16 | — | — | US | disclosed |
| US-20030203913-A1 | Beta3 adrenergic receptor agonists and uses thereof | PFIZER INC. | 2003-10-30 | — | — | US | disclosed |
| EP-1326861-A1 | ALPHA-ARYL ETHANOLAMINES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | Pfizer Products Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032897-A1 | ALPHA-ARYL ETHANOLAMINES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203913-A1 | Beta3 adrenergic receptor agonists and uses thereof | ADRB3, ADRB1, ADRB2 | ADRB3 1/4885ADRB1 2/4885ADRB2 3/4885 |
| US-20050075323-A1 | Beta3 adrenergic receptor agonists and uses thereof | ADRB3, ADRB1, ADRB2 | ADRB3 1/4885ADRB1 2/4885ADRB2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.