Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19744010 | 0.94 | KDM4E (0.58) | KDM4EALDH1A1AKR1B1GPR35USP2 | |
| SCHEMBL5560761 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1AKR1B1GPR35USP2 | |
| SCHEMBL5564628 | 0.84 | KDM4E (0.61) | KDM4EALDH1A1AKR1B1USP2CSNK2A2 | |
| SCHEMBL6331783 | 0.83 | AKR1B1 (0.58) | KDM4EALDH1A1AKR1B1GPR35USP2 | |
| SCHEMBL6329297 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1AKR1B1USP2CSNK2A2 | |
| SCHEMBL6331400 | 0.78 | AKR1B1 (0.50) | KDM4EALDH1A1AKR1B1GPR35USP2 | |
| SCHEMBL6332065 | 0.78 | ALDH1A1 (0.59) | KDM4EALDH1A1AKR1B1GPR35USP2 | |
| SCHEMBL6333731 | 0.78 | AKR1B1 (0.53) | KDM4EALDH1A1AKR1B1GPR35USP2 | |
| SCHEMBL6331382 | 0.77 | MCHR1 (0.52) | KCNH2MCHR1TP53ACHEALOX5 | |
| SCHEMBL6331379 | 0.76 | MCHR1 (0.60) | KCNH2MCHR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209274-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABOTT LABORATORIES | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209274-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | KDM4E 2305/4885ALDH1A1 1308/4885AKR1B1 1927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.