Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.73 |
| ▸ | TTR | P02766 | 2/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | TYR | P14679 | 2/20 | 0.60 |
| ▸ | CA7 | P43166 | 2/20 | 0.60 |
| ▸ | CA9 | Q16790 | 2/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329457 | 1.00 | APP (0.73) | APPTTRPTPN1EPHX2CA12 | |
| SCHEMBL11222383 | 0.87 | APP (0.73) | APPTTRPTPN1EPHX2CA12 | |
| SCHEMBL29913987 | 0.87 | APP (0.73) | APPTTRPTPN1EPHX2CA12 | |
| SCHEMBL11222387 | 0.87 | APP (0.73) | APPTTRPTPN1EPHX2CA12 | |
| SCHEMBL5225706 | 0.87 | TTR (0.63) | APPTTRPTPN1EPHX2CA12 | |
| Methylcaffeate SCHEMBL198252 | 0.85 | APP (1.00) | APPTTRPTPN1EPHX2CA12 | |
| Methylcaffeate SCHEMBL30637688 | 0.85 | APP (1.00) | APPTTRPTPN1EPHX2CA12 | |
| Methylcaffeate SCHEMBL30963730 | 0.85 | APP (1.00) | APPTTRPTPN1EPHX2CA12 | |
| Methylcaffeate SCHEMBL817520 | 0.85 | APP (1.00) | APPTTRPTPN1EPHX2CA12 | |
| SCHEMBL2261784 | 0.83 | TTR (0.76) | APPTTRCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209274-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABOTT LABORATORIES | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209274-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | APP 1483/4885TTR 550/4885PTPN1 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.