Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584763 | 0.83 | KDR (0.57) | HPGDALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL11650826 | 0.80 | HPGD (0.55) | HPGDSMN1; SMN2ALDH1A1HDAC3HDAC4 | |
| SCHEMBL4252563 | 0.79 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11HPGD | |
| SCHEMBL12788248 | 0.79 | PPARA (0.69) | HPGDSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL3817565 | 0.79 | CSNK2A2 (0.53) | HPGDSMN1; SMN2RAB9ALMNAHDAC3 | |
| SCHEMBL8283721 | 0.77 | PPARA (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2ANAMPT | |
| SCHEMBL24498387 | 0.77 | HPGDS (0.49) | HPGDALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL3585085 | 0.76 | CCNE1 (0.65) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL18529252 | 0.75 | ATG4B (0.60) | NAMPT | |
| SCHEMBL1657000 | 0.75 | GRM5 (0.54) | HPGDHDAC3HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050228031-A1 | Tyrosine kinase inhibitors | BILODEAU MARK T | 2005-10-13 | — | — | US | claimed |
| US-20050228031-A1 | Tyrosine kinase inhibitors | BILODEAU MARK T | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228031-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | MAPK14 161/4885MAPK13 175/4885MAPK12 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.