Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13218358 | 0.79 | PIK3CD (0.55) | ALDH1A1FAAHMEN1KMT2AMAPK1 | |
| SCHEMBL2049323 | 0.78 | ALDH1A1 (0.49) | ALDH1A1FAAHMEN1KMT2AHRH3 | |
| SCHEMBL9672550 | 0.77 | ALDH1A1 (0.52) | ALDH1A1FAAHMEN1KMT2AMAPK1 | |
| SCHEMBL27735475 | 0.76 | CYP1A2 (0.39) | MAPK1 | |
| SCHEMBL27735477 | 0.76 | CYP1A2 (0.39) | MAPK1 | |
| SCHEMBL9462903 | 0.74 | ALDH1A1 (0.57) | ALDH1A1FAAHMEN1KMT2AMAPK1 | |
| SCHEMBL9829055 | 0.73 | ALDH1A1 (0.47) | ALDH1A1FAAHMEN1KMT2AMAPK1 | |
| SCHEMBL871714 | 0.73 | ALDH1A1 (0.52) | ALDH1A1FAAHMEN1KMT2AMAPK1 | |
| SCHEMBL9829061 | 0.73 | ALDH1A1 (0.47) | ALDH1A1FAAHMEN1KMT2AMAPK1 | |
| SCHEMBL6330220 | 0.73 | ALDH1A1 (0.56) | ALDH1A1FAAHMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943163-B2 | 7-Alkyl and cycloalkyl-substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2005-09-13 | — | — | US | disclosed |
| US-20050049250-A1 | 7-Aikyl and cycloalkyl-substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-03 | — | — | US | disclosed |
| US-6838459-B1 | 7-alkyl-and cycloalkyl-substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2005-01-04 | — | — | US | disclosed |
| US-6476029-B1 | 7-alkyl- and cycloalkyl-substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2002-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049250-A1 | 7-Aikyl and cycloalkyl-substituted imidazotriazinones | PDE3A, PDE2A, PDE3B | ALDH1A1 537/4885FAAH 1107/4885MEN1 4113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.