Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | MMP2 | P08253 | 4/20 | 0.73 |
| ▸ | MMP9 | P14780 | 4/20 | 0.73 |
| ▸ | MMP8 | P22894 | 4/20 | 0.73 |
| ▸ | MMP13 | P45452 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 3/20 | 0.73 |
| ▸ | CASP3 | P42574 | 2/20 | 0.73 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.73 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.73 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.73 |
| ▸ | NPBWR1 | P48145 | 11/20 | 0.70 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330461 | 0.90 | NPC1 (0.61) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL30343727 | 0.90 | NPC1 (0.61) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL30726440 | 0.86 | RAB9A (0.75) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL27040204 | 0.86 | RAB9A (0.75) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL5566191 | 0.85 | NPC1 (1.00) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL3204662 | 0.84 | RAB9A (0.75) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL20982761 | 0.83 | NPC1 (0.97) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL6325684 | 0.83 | NPC1 (0.79) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL20982700 | 0.82 | NPC1 (0.94) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL22439772 | 0.80 | NPC1 (0.79) | NPC1MAPTRAB9AMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050277686-A1 | Benzimidazole compounds for regulating IgE | SIRCAR JAGADISH C | 2005-12-15 | — | — | US | disclosed |
| US-6911462-B2 | Benzimidazole compounds for regulating IgE | AVANIR PHARMACEUTICALS (US) | 2005-06-28 | — | — | US | disclosed |
| US-20030100582-A1 | Benzimidazole compounds for regulating IgE | AVANIR PHARMACEUTICALS | 2003-05-29 | — | — | US | disclosed |
| US-6369091-B1 | ANTIALLERGENS | AVANIR PHARMACEUTICALS | 2002-04-09 | — | — | US | disclosed |
| EP-1079830-A1 | BENZIMIDAZOLE ANALOGS AS DOWN-REGULATORS OF IgE | Avanir Pharmaceuticals (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061020-A1 | BENZIMIDAZOLE ANALOGS AS DOWN-REGULATORS OF IgE | AVANIR PHARMACEUTICALS (US) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100582-A1 | Benzimidazole compounds for regulating IgE | FCER2, SERPINB1, BRPF3 | NPC1 3329/4885MAPT 3023/4885RAB9A 4088/4885 |
| US-20050277686-A1 | Benzimidazole compounds for regulating IgE | FCER2, SERPINB1, BRPF3 | NPC1 3329/4885MAPT 3023/4885RAB9A 4088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.