Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434336 | 0.77 | ALDH1A1 (0.48) | GAPDHCMKLR1 | |
| SCHEMBL26632991 | 0.73 | — | — | |
| SCHEMBL4439607 | 0.72 | — | — | |
| SCHEMBL10250125 | 0.72 | — | — | |
| SCHEMBL9176329 | 0.72 | — | — | |
| SCHEMBL4439604 | 0.72 | — | — | |
| SCHEMBL9176333 | 0.72 | — | — | |
| SCHEMBL3398848 | 0.71 | GAPDH (0.60) | GAPDHCMKLR1 | |
| SCHEMBL3398850 | 0.71 | GAPDH (0.60) | GAPDHCMKLR1 | |
| SCHEMBL3281352 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023875-B2 | Macrocyclic compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-8759512-B2 | Methods of preparation of macrocyclic compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20140031400-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-8357708-B2 | Macrocyclic compounds and methods of treatment | University of Florida Resesarch Foundation, Inc. (US) | 2013-01-22 | — | — | US | disclosed |
| EP-2543383-A1 | Macrocyclic compounds and methods of treatment | University of Florida Research Foundation, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| EP-2190449-B1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIV FLORIDA (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20120095065-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8129418-B2 | Macrocyclic compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110118323-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-20110092697-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2011-04-21 | — | — | US | disclosed |
| EP-2190449-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | University of Florida Research Foundation, Inc. (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009105284-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009032352-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118323-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | GAPDH 1384/4885CMKLR1 2017/4885 |
| US-20120095065-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | GAPDH 1384/4885CMKLR1 2017/4885 |
| US-20110092697-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | MKI67, CCNC, PCNA | GAPDH 1560/4885CMKLR1 3385/4885 |
| US-20140031400-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | GAPDH 1384/4885CMKLR1 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.