Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927546 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4CYP2D6 | |
| SCHEMBL12066938 | 0.77 | CYP2D6 (0.44) | CHRNB4CHRNA3CYP2D6ALDH1A1HPGD | |
| SCHEMBL649311 | 0.77 | CYP2D6 (0.44) | CHRNB4CHRNA3CYP2D6ALDH1A1HPGD | |
| SCHEMBL1617746 | 0.77 | CYP2D6 (0.44) | CHRNB4CHRNA3CYP2D6ALDH1A1HPGD | |
| SCHEMBL650751 | 0.77 | CYP2D6 (0.44) | CHRNB4CHRNA3CYP2D6ALDH1A1HPGD | |
| SCHEMBL20079103 | 0.77 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16764864 | 0.76 | MEN1 (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17228501 | 0.75 | CYP2D6 (0.40) | CYP2D6ALDH1A1HPGDSLC6A2SLC6A4 | |
| SCHEMBL20121091 | 0.74 | ALDH1A1 (0.43) | CHRNB4CHRNA3CYP2D6ALDH1A1HPGD | |
| SCHEMBL6980888 | 0.74 | ALDH1A1 (0.43) | CHRNB4CHRNA3CYP2D6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | ABBOTT LABORATORIES | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | CHRNA7, CHRNA1, CHRNA5 | CHRNB2 12/4885CHRNB4 25/4885CHRNA3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.