Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149011 | 0.82 | HSD11B1 (0.47) | HSD11B1GBA1MAP4K4NPC1KDM1A | |
| SCHEMBL6057032 | 0.82 | — | — | |
| SCHEMBL4893194 | 0.82 | HSD11B1 (0.47) | HSD11B1GBA1MAP4K4NPC1KDM1A | |
| SCHEMBL1783124 | 0.79 | HSD11B1 (0.41) | HSD11B1GBA1MAP4K4NPC1KDM1A | |
| SCHEMBL18725913 | 0.76 | DRD2 (0.39) | — | |
| SCHEMBL12125906 | 0.76 | HSD11B1 (0.41) | HSD11B1GBA1MAP4K4NPC1KDM1A | |
| SCHEMBL84800 | 0.75 | HSD11B1 (0.43) | HSD11B1GBA1NPC1 | |
| SCHEMBL21664675 | 0.73 | HSD11B1 (0.42) | HSD11B1GBA1TDP1 | |
| SCHEMBL793514 | 0.73 | DRD2 (0.44) | HSD11B1GBA1NPC1 | |
| SCHEMBL10930283 | 0.73 | HSD11B1 (0.42) | HSD11B1GBA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234992-B1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2012-02-22 | — | — | EP | claimed |