Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6333049 | 1.00 | USP30 (0.40) | USP30HDAC1HDAC2HDAC4HDAC6 | |
| SCHEMBL6333050 | 1.00 | USP30 (0.40) | USP30HDAC1HDAC2HDAC4HDAC6 | |
| SCHEMBL6334323 | 0.88 | ALDH1A1 (0.43) | USP30GPR119MEN1KMT2APDE4B | |
| SCHEMBL6337321 | 0.88 | ALDH1A1 (0.43) | USP30GPR119MEN1KMT2APDE4B | |
| SCHEMBL6337325 | 0.88 | ALDH1A1 (0.43) | USP30GPR119MEN1KMT2APDE4B | |
| SCHEMBL6334320 | 0.88 | ALDH1A1 (0.43) | USP30GPR119MEN1KMT2APDE4B | |
| SCHEMBL6334317 | 0.88 | ALDH1A1 (0.43) | USP30GPR119MEN1KMT2APDE4B | |
| SCHEMBL6333294 | 0.85 | GPR119 (0.39) | USP30HDAC1HDAC2TACR1GPR119 | |
| SCHEMBL6333295 | 0.85 | GPR119 (0.39) | USP30HDAC1HDAC2TACR1GPR119 | |
| SCHEMBL6333298 | 0.85 | GPR119 (0.39) | USP30HDAC1HDAC2TACR1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1204659-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009122-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |