Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326450 | 0.90 | ALDH1A1 (0.54) | ALDH1A1LMNAGAANPSR1TSHR | |
| SCHEMBL6330590 | 0.87 | TSHR (0.46) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL6333326 | 0.86 | NPSR1 (0.50) | ALDH1A1LMNAGAANPSR1TSHR | |
| SCHEMBL6333338 | 0.84 | LMNA (0.48) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL6332651 | 0.82 | ALDH1A1 (0.51) | ALDH1A1LMNAGAANPSR1TSHR | |
| SCHEMBL6328017 | 0.82 | ALDH1A1 (0.53) | ALDH1A1LMNAGAANPSR1TSHR | |
| SCHEMBL6326482 | 0.80 | HPGD (0.44) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL6327952 | 0.79 | KMT2A (0.40) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL6332476 | 0.79 | NPSR1 (0.47) | ALDH1A1LMNAGAANPSR1TSHR | |
| SCHEMBL6330709 | 0.78 | ALDH1A1 (0.47) | ALDH1A1LMNAGAANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |