Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 12/20 | 0.43 |
| ▸ | KDR | P35968 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787031 | 0.90 | GAA (0.48) | GAAMAPTSMN1; SMN2RXFP1BRD9 | |
| SCHEMBL5791728 | 0.88 | SMN1; SMN2 (0.49) | GAAMAPTSMN1; SMN2RXFP1TGFBR1 | |
| SCHEMBL5787767 | 0.85 | TGFBR1 (0.49) | SMN1; SMN2TGFBR1KDRALDH1A1KDM4E | |
| SCHEMBL5786049 | 0.84 | USP7 (0.48) | GAAMAPTSMN1; SMN2TGFBR1KDR | |
| SCHEMBL5788266 | 0.81 | TGFBR1 (0.43) | GAAMAPTSMN1; SMN2TGFBR1KDR | |
| SCHEMBL5789755 | 0.79 | MAPT (0.47) | GAAMAPTSMN1; SMN2BRD9BAZ2B | |
| SCHEMBL5788026 | 0.79 | HRH3 (0.49) | TGFBR1 | |
| SCHEMBL5786499 | 0.79 | BACE1 (0.40) | GAAMAPTSMN1; SMN2TGFBR1KDR | |
| SCHEMBL5789640 | 0.78 | TGFBR1 (0.49) | GAASMN1; SMN2TGFBR1KDRALDH1A1 | |
| SCHEMBL5787113 | 0.78 | GAA (0.41) | GAAMAPTSMN1; SMN2TGFBR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | DODIC NERINA | 2005-11-03 | — | — | US | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | SMAD2, SMAD3, ALK | GAA 1784/4885MAPT 1496/4885SMN1; SMN2 2815/4885 |
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | GAA 1767/4885MAPT 1376/4885SMN1; SMN2 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.