Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18725913 | 0.80 | DRD2 (0.39) | ALDH1A1 | |
| SCHEMBL262312 | 0.76 | — | — | |
| SCHEMBL84808 | 0.76 | CHRNA7 (0.48) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E | |
| SCHEMBL577415 | 0.76 | CHRNA7 (0.48) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E | |
| SCHEMBL577052 | 0.76 | CHRNA7 (0.48) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E | |
| SCHEMBL6657817 | 0.76 | CHRNA7 (0.48) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E | |
| SCHEMBL1206778 | 0.74 | MAOB (0.40) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E | |
| SCHEMBL553964 | 0.74 | ALDH1A1 (0.39) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E | |
| Ammonia Solution, Strong SCHEMBL4249875 | 0.73 | — | — | |
| Iodide SCHEMBL11554007 | 0.73 | CHRNA7 (0.46) | SMN1; SMN2CHRNA7HSD11B1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176170-B1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE HOLDINGS CORP (US) | 2018-11-14 | — | — | EP | claimed |
| EP-2824108-B1 | TETRACYCLIC ANTHRAQUINONE DERIVATIVES | TIANJIN HEMAY BIO-TECH CO LTD (CN) | 2017-04-19 | — | — | EP | claimed |
| EP-2234992-B1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2012-02-22 | — | — | EP | claimed |
| EP-1647555-B1 | THE C-GLYCOSYLISOFLAVONES HAVING ALKYLAMINOALKOXYL SUBSTITUENT, THE PREPARATION AND THE USE OF THE SAME | INST RADIATION MED AMMS PLA (CN) | 2011-04-20 | — | — | EP | claimed |
| EP-1838712-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | claimed |