Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.95 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.49 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.49 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.49 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.49 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.49 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.49 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.49 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.49 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.48 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274906 | 0.98 | TMEM97 (1.00) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| Hydrochloric Acid SCHEMBL5115776 | 0.95 | TMEM97 (0.95) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| SCHEMBL11539730 | 0.95 | TMEM97 (0.95) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| Hydrochloric Acid SCHEMBL28659483 | 0.93 | TMEM97 (0.91) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| Hydrochloric Acid SCHEMBL27960798 | 0.93 | TMEM97 (0.91) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| Tyramine SCHEMBL27589422 | 0.88 | TMEM97 (0.81) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| Nitrous Acid SCHEMBL18329343 | 0.88 | TMEM97 (0.81) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| SCHEMBL579569 | 0.86 | TMEM97 (0.78) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| SCHEMBL10156581 | 0.85 | TAAR1 (0.76) | TMEM97SIGMAR1TAAR1MAPTHIF1A | |
| Nitric Acid SCHEMBL18329335 | 0.85 | TMEM97 (0.75) | TMEM97SIGMAR1TAAR1MAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113683522-A | Preparation method of N-methyltyramine hydrochloride | 广汉市派瑞林科技有限责任公司 | 2021-11-23 | — | — | CN | claimed |
| CN-113683522-A | Preparation method of N-methyltyramine hydrochloride | 广汉市派瑞林科技有限责任公司 | 2021-11-23 | — | — | CN | disclosed |
| US-6943162-B2 | Osteoporosis; cardiovascular disorders; anticancer agents;incontinence | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040072829-A1 | Piperazinyltriazines as estrogen receptor modulators | SMITHKLINE BEECHAM CORPORATION | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072829-A1 | Piperazinyltriazines as estrogen receptor modulators | GPER1, ESR2, ESR1 | SIGMAR1 115/4885SLC6A2 4242/4885ADRA1A 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.