Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.88 |
| ▸ | MAOB | P27338 | 3/20 | 0.88 |
| ▸ | MGAM | O43451 | 1/20 | 0.88 |
| ▸ | MAOA | P21397 | 1/20 | 0.88 |
| ▸ | XDH | P47989 | 1/20 | 0.88 |
| ▸ | AKT1 | P31749 | 1/20 | 0.76 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stipulin SCHEMBL633710 | 1.00 | PTPN1 (0.88) | PTPN1MAOBMGAMMAOAXDH | |
| Stipulin SCHEMBL29435847 | 1.00 | PTPN1 (0.88) | PTPN1MAOBMGAMMAOAXDH | |
| Broussochalcone A SCHEMBL32689658 | 0.94 | PTPN1 (1.00) | PTPN1MAOBMGAMMAOAXDH | |
| Broussochalcone A SCHEMBL431919 | 0.94 | PTPN1 (1.00) | PTPN1MAOBMGAMMAOAXDH | |
| SCHEMBL26552077 | 0.91 | PTPN1 (0.82) | PTPN1MAOBMGAMMAOAXDH | |
| Broussochalcone B SCHEMBL2807434 | 0.90 | PTPN1 (0.80) | PTPN1MAOBMGAMMAOAXDH | |
| Broussochalcone B SCHEMBL1576619 | 0.90 | PTPN1 (0.80) | PTPN1MAOBMGAMMAOAXDH | |
| SCHEMBL26552063 | 0.89 | PTPN1 (0.82) | PTPN1MAOBMGAMMAOAXDH | |
| SCHEMBL19960676 | 0.89 | PTPN1 (0.78) | PTPN1MAOBMGAMMAOAXDH | |
| SCHEMBL26552074 | 0.88 | PTPN1 (0.77) | PTPN1MAOBMGAMMAOAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888174-B1 | USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS | JOHNSON & JOHNSON CONSUMER (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-1888174-A1 | USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS | Johnson and Johnson Consumer Companies, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006127539-A1 | USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060270614-A1 | Use of chalcones for the treatment of viral disorders | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270614-A1 | Use of chalcones for the treatment of viral disorders | HAVCR2, HMGB3, EIF2AK2 | PTPN1 2767/4885MAOB 3343/4885MGAM 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.