Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2133610 | 0.80 | ALDH1A1 (0.65) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL6795094 | 0.73 | MEN1 (0.44) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL6802135 | 0.69 | ALDH1A1 (0.64) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL1810147 | 0.69 | SRD5A2 (0.69) | MAPTALDH1A1GAALMNAPOLB | |
| SCHEMBL13633822 | 0.68 | ALDH1A1 (0.78) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL9865195 | 0.67 | LMNA (0.52) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL9864961 | 0.66 | ALDH1A1 (0.69) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL9864830 | 0.65 | ALDH1A1 (0.68) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL4465841 | 0.65 | MAPT (0.84) | MAPTALDH1A1GAAKDM4EHPGD | |
| SCHEMBL3434460 | 0.65 | CDK5 (0.46) | MAPTALDH1A1GAAHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419424-A2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | Telik, Inc. (US) | 2012-02-22 | — | — | EP | claimed |
| WO-2010120400-A2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | TELIK, INC. (US) | 2010-10-21 | — | — | WO | claimed |