Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.90 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.90 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL5684638 | 1.00 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL9037865 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Benzene SCHEMBL1261317 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL16 | 0.95 | — | — | |
| Pyridine SCHEMBL180431 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Benzene SCHEMBL10751789 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| SCHEMBL3052767 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL933604 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL1654468 | 0.95 | — | — | |
| SCHEMBL34466311 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198497-B2 | Oligomerization catalyst; zirconium tetrachloride diphenylsulfone; zirconium tetrachloride diethylsulfone | POLIMERI EUROPA S.P.A. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-20050070425-A1 | Catalytic composition and process for the selective oligomerization of ethylene to light linear alpha-olefins | POLIMERI EUROPA S.P.A (IT) | 2005-03-31 | — | — | US | disclosed |
| EP-1453604-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | Polimeri Europa S.r.l. (IT) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003053573-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | POLIMERI EUROPA S.P.A. (IT) | 2003-07-03 | — | — | WO | disclosed |