⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL3926229 | 1.00 | ALDH1A1 (0.31) | — | |
| Fluoride SCHEMBL1062136 | 1.00 | ALDH1A1 (0.31) | — | |
| Fluoride SCHEMBL28235374 | 0.95 | — | — | |
| Fluoride Ion SCHEMBL963997 | 0.95 | — | — | |
| Fluoride Ion SCHEMBL131861 | 0.95 | ALDH1A1 (0.33) | — | |
| Fluoride SCHEMBL1263596 | 0.95 | — | — | |
| Fluoride SCHEMBL6229645 | 0.95 | — | — | |
| SCHEMBL1334882 | 0.91 | — | — | |
| Fluoride SCHEMBL13581787 | 0.91 | ALDH1A1 (0.36) | — | |
| Fluoride SCHEMBL99441 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100076-B2 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | GILEAD PHARMASSET LLC (US) | 2018-10-16 | — | — | US | disclosed |
| EP-1028124-B2 | Improved deprotection method for the synthesis of oligomeric compounds | ISIS PHARMACEUTICALS INC (US) | 2016-01-27 | — | — | EP | disclosed |
| US-9051501-B2 | Curable composition and catalyst composition | KANEKA CORPORATION (JP) | 2015-06-09 | — | — | US | disclosed |
| US-20140057863-A1 | MODIFIED NUCLEOSIDES FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | GILEAD SCIENCES, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| EP-2251015-B1 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | GILEAD PHARMASSET LLC (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-2088173-B1 | CURABLE COMPOSITION AND CATALYST COMPOSITION | KANEKA CORP (JP) | 2012-02-22 | — | — | EP | disclosed |
| US-20110269707-A1 | Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation | PHARMASSET, INC. | 2011-11-03 | — | — | US | disclosed |
| EP-2302000-A1 | Curable composition and catalyst composition | KANEKA CORPORATION (JP) | 2011-03-30 | — | — | EP | disclosed |
| EP-1411954-B1 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET INC (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-2251015-A1 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | Pharmasset, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| US-20030087873-A1 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | PHARMASSET, INC. | 2003-05-08 | — | — | US | disclosed |
| US-20030088088-A1 | Process for the synthesis of oligomeric compounds | IONIS PHARMACEUTICALS, INC. | 2003-05-08 | — | — | US | disclosed |
| US-6465628-B1 | METHOD OF SYNTHESIS WITH DEPROTECTION OF OLIGOMERS | ISIS PHARMACEUTICALS, INC. | 2002-10-15 | — | — | US | disclosed |
| WO-2002078619-A2 | ALKYNYLATED SINGLE-STRAND OLIGONUCLEOTIDE AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002072864-A2 | REAGENTS FOR OLIGONUCLEOTIDE CLEAVAGE AND DEPROTECTION | APPLERA CORPORATION (US) | 2002-09-19 | — | — | WO | disclosed |
| EP-1232166-A2 | SYNTHESIS OF 2'-DEOXY-L-NUCLEOSIDES | Pharmasset Limited (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2002048165-A2 | ANTIVIRAL AGENTS FOR TREATMENT OF FLAVIVIRIDAE INFECTIONS | PHARMASSET LTD. (BB) | 2002-06-20 | — | — | WO | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |
| WO-2001034618-A2 | SYNTHESIS OF 2'-DEOXY-L-NUCLEOSIDES | PHARMASSET LIMITED (US) | 2001-05-17 | — | — | WO | disclosed |
| EP-1028124-A2 | Improved process for the synthesis of oligomeric compounds | ISIS PHARMACEUTICALS, INC. (US) | 2000-08-16 | — | — | EP | disclosed |