Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.61 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.61 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.61 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6341165 | 0.82 | SIGMAR1 (0.56) | SIGMAR1FPR3FPR2 | |
| SCHEMBL5467668 | 0.81 | GRIN2D (0.85) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6925661 | 0.81 | GRIN2D (0.85) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6923829 | 0.81 | GRIN2D (0.85) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7761906 | 0.80 | GRIN2D (0.81) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7760009 | 0.80 | GRIN2D (0.81) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL5461681 | 0.80 | GRIN2D (0.81) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL6338933 | 0.79 | SIGMAR1 (0.49) | SIGMAR1FPR3FPR2 | |
| SCHEMBL6015497 | 0.78 | GRIN2D (0.78) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1273740 | 0.78 | GRIN2D (0.78) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-B1 | HISTAMINE H3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2004-01-07 | — | — | EP | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |