Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CCKBR | P32239 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GRN | P28799 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634229 | 0.77 | SLC6A3 (0.52) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL31061196 | 0.72 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL769423 | 0.72 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL21496986 | 0.71 | TAS1R3 (0.45) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL634228 | 0.71 | SLC6A4 (0.56) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL2291278 | 0.71 | SLC6A4 (0.56) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL5276135 | 0.69 | SLC6A4 (0.49) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL30471204 | 0.69 | HPGD (0.53) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL29018410 | 0.69 | HPGD (0.53) | SLC6A4SLC6A3SLC6A2TSHRHPGD | |
| SCHEMBL634330 | 0.69 | HSD17B3 (0.58) | TSHRHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419400-A1 | MONOAMINE REUPTAKE INHIBITORS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010121022-A1 | MONOAMINE REUPTAKE INHIBITORS | RESEARCH TRIANGLE INSTITUTE (US) | 2010-10-21 | — | — | WO | disclosed |