Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.50 |
| ▸ | CCR5 | P51681 | 14/20 | 0.49 |
| ▸ | CCR7 | P32248 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031959 | 0.92 | CCR2 (0.53) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6340388 | 0.91 | CCR2 (0.48) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL3029085 | 0.90 | CCR2 (0.56) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6342702 | 0.90 | CCR2 (0.53) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6340941 | 0.90 | CCR5 (0.58) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6350331 | 0.89 | CCR2 (0.51) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6344036 | 0.89 | CCR5 (0.52) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6341391 | 0.89 | CCR2 (0.50) | CCR2CCR5CCR7CCR3CCR4 | |
| Hydrochloric Acid SCHEMBL6341832 | 0.89 | CCR2 (0.52) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6351902 | 0.89 | CCR2 (0.50) | CCR2CCR5CCR7CCR3CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |