SCHEMBL6340720

SCHEMBL6340720

COC(=O)c1ccccc1NC(=O)Cc1ccc(Oc2ccc3cc(OCc4ccccc4)ccc3c2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
KDM4E B2RXH2 5/20 0.52
TSHR P16473 2/20 0.52
MAPK10 P53779 2/20 0.52
HSD17B10 Q99714 2/20 0.52
HPGD P15428 3/20 0.52
MAPT P10636 2/20 0.52
KMT2A Q03164 3/20 0.50
HCAR2 Q8TDS4 2/20 0.49
POLB P06746 3/20 0.49
MEN1 O00255 2/20 0.49
PPARG P37231 2/20 0.49
NCOA2 Q15596 2/20 0.49
NCOA1 Q15788 2/20 0.49
NCOA3 Q9Y6Q9 2/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6349020 0.92 ALDH1A1 (0.60) ALDH1A1KDM4ETSHRMAPK10HSD17B10
SCHEMBL14513318 0.90 MEN1 (0.61) ALDH1A1KDM4EKMT2AHCAR2POLB
SCHEMBL6338905 0.88 KDM4E (0.47) ALDH1A1KDM4ETSHRMAPK10HSD17B10
SCHEMBL8041179 0.88 ALDH1A1 (0.52) ALDH1A1KDM4ETSHRMAPK10HSD17B10
SCHEMBL6337230 0.88 KMT2A (0.53) ALDH1A1KDM4ETSHRMAPK10HSD17B10
Benzoic Acid SCHEMBL8041305 0.88 ALDH1A1 (0.55) ALDH1A1KDM4ETSHRMAPK10HSD17B10
SCHEMBL6336997 0.86 MAPT (0.66) ALDH1A1KDM4ETSHRHSD17B10HPGD
SCHEMBL6337445 0.86 KMT2A (0.46) ALDH1A1KDM4ETSHRMAPK10HSD17B10
SCHEMBL8027767 0.85 ALDH1A1 (0.61) ALDH1A1KDM4ETSHRMAPK10HSD17B10
SCHEMBL8027783 0.84 ALDH1A1 (0.48) ALDH1A1KDM4ETSHRMAPK10HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6890932-B2 Immunoglobulin e antibody suppressors TEIJIN LIMITED (JP) 2005-05-10 US disclosed
US-20050027008-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredient TEIJIN LIMITED 2005-02-03 US disclosed
EP-1101755-B1 ANTHRANILIC ACID DERIVATIVES TEIJIN LTD (JP) 2004-10-06 EP disclosed
US-20030232811-A1 Immunoglobulin e antibody suppressors TEIJIN LIMITED 2003-12-18 US disclosed
US-20030220402-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredients TEIJIN LIMITED (JP) 2003-11-27 US disclosed
US-6649656-B1 Anticarcinogenic, antiallergen, antishock, and antiasthmatic agents TEIJIN LIMITED (JP) 2003-11-18 US disclosed
EP-1256341-A1 CANCER REMEDY COMPRISING ANTHRANILIC ACID DERIVATIVE AS ACTIVE INGREDIENT TEIJIN LIMITED (JP) 2002-11-13 EP disclosed
EP-1101755-A1 ANTHRANILIC ACID DERIVATIVES TEIJIN LIMITED (JP) 2001-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030220402-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredients HCCS, BCOR, CBR1 ALDH1A1 1126/4885KDM4E 1406/4885TSHR 2490/4885
US-20050027008-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredient CA9, HCCS, CA7 ALDH1A1 1389/4885KDM4E 1879/4885TSHR 1292/4885
US-20030232811-A1 Immunoglobulin e antibody suppressors IGLV6-57, FCGRT, IGSF11 ALDH1A1 250/4885KDM4E 875/4885TSHR 3574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.