Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.62 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.55 |
| ▸ | EBP | Q15125 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9391019 | 0.88 | SIGMAR1 (0.57) | SIGMAR1SLC18A3OPRL1ADRA1AMCHR1 | |
| SCHEMBL6396038 | 0.87 | SIGMAR1 (0.54) | SIGMAR1SLC18A3OPRL1ALDH1A1TP53 | |
| SCHEMBL4977716 | 0.85 | SIGMAR1 (0.57) | SIGMAR1SLC18A3EBPOPRL1ADRA1A | |
| SCHEMBL4977710 | 0.85 | SIGMAR1 (0.57) | SIGMAR1SLC18A3EBPOPRL1ADRA1A | |
| SCHEMBL4978282 | 0.82 | SIGMAR1 (0.67) | SIGMAR1SLC18A3OPRL1ALDH1A1TP53 | |
| SCHEMBL4978278 | 0.82 | SIGMAR1 (0.67) | SIGMAR1SLC18A3OPRL1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL6395819 | 0.81 | SIGMAR1 (0.67) | SIGMAR1SLC18A3OPRL1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL6395234 | 0.80 | SIGMAR1 (0.62) | SIGMAR1SLC18A3OPRL1ALDH1A1TP53 | |
| SCHEMBL6396816 | 0.79 | IDO1 (0.50) | SIGMAR1OPRL1ALDH1A1TP53CYP1A2 | |
| SCHEMBL12199153 | 0.77 | KCNH2 (0.59) | SIGMAR1OPRL1ADRA1AMCHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869960-B2 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor | PFIZER INC. (US) | 2005-03-22 | — | — | US | disclosed |
| US-20050038060-A1 | Spiropoperidine compounds as ligands for orl-1 receptor | ANDO KOJI (JP) | 2005-02-17 | — | — | US | disclosed |
| EP-1470126-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-10-27 | — | — | EP | disclosed |
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| US-20030158219-A1 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor | ITO FUMITAKA (JP) | 2003-08-21 | — | — | US | disclosed |
| WO-2003064425-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER JAPAN INC. (JP) | 2003-08-07 | — | — | WO | disclosed |
| US-20030078279-A1 | Spiropiperidine compounds as ligands for ORL-1receptor | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
| US-20030078278-A1 | Spiropiperidine compounds as ligands for ORL-1 receptor | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158219-A1 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor | OGFRL1, OXER1, ORMDL3 | SIGMAR1 13/4885SLC18A3 2247/4885EBP 1755/4885 |
| US-20030078278-A1 | Spiropiperidine compounds as ligands for ORL-1 receptor | OPRL1, OPRD1, OXER1 | SIGMAR1 9/4885SLC18A3 3333/4885EBP 1902/4885 |
| US-20030078279-A1 | Spiropiperidine compounds as ligands for ORL-1receptor | OPRL1, OPRD1, OXER1 | SIGMAR1 13/4885SLC18A3 3251/4885EBP 1462/4885 |
| US-20050038060-A1 | Spiropoperidine compounds as ligands for orl-1 receptor | OPRL1, OXER1, OGFRL1 | SIGMAR1 11/4885SLC18A3 3518/4885EBP 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.