Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of 1-Naphthoquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | CCR1 | P32246 | 5/20 | 0.65 |
| ▸ | CCR8 | P51685 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | CCR5 | P51681 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | MMP8 | P22894 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthoquinoline SCHEMBL15106 | 0.98 | LMNA (0.69) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL29533982 | 0.98 | LMNA (0.69) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL31141994 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL31286254 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL30862227 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL6826374 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL3045500 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL5572864 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| SCHEMBL3193877 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT | |
| 1-Naphthoquinoline SCHEMBL262791 | 0.95 | LMNA (0.67) | LMNACCR1CCR8KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198497-B2 | Oligomerization catalyst; zirconium tetrachloride diphenylsulfone; zirconium tetrachloride diethylsulfone | POLIMERI EUROPA S.P.A. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-20050070425-A1 | Catalytic composition and process for the selective oligomerization of ethylene to light linear alpha-olefins | POLIMERI EUROPA S.P.A (IT) | 2005-03-31 | — | — | US | disclosed |
| EP-1453604-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | Polimeri Europa S.r.l. (IT) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003053573-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | POLIMERI EUROPA S.P.A. (IT) | 2003-07-03 | — | — | WO | disclosed |