Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6516899 | 0.89 | LMNA (0.45) | LMNAPMP22NPSR1GFERCYP1A2 | |
| SCHEMBL6341939 | 0.88 | CYP1A2 (0.36) | LMNAPMP22NPSR1GFERCYP1A2 | |
| SCHEMBL6350680 | 0.87 | LMNA (0.40) | LMNAPMP22NPSR1GFERCYP1A2 | |
| SCHEMBL6525034 | 0.82 | LMNA (0.41) | LMNAPMP22NPSR1GFERCYP1A2 | |
| SCHEMBL6520807 | 0.82 | LMNA (0.41) | LMNAPMP22NPSR1GFERCYP1A2 | |
| SCHEMBL6352550 | 0.82 | HRH2 (0.39) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL6516859 | 0.80 | KMT2A (0.46) | LMNAPMP22NPSR1GFERMEN1 | |
| SCHEMBL6516854 | 0.80 | KMT2A (0.46) | LMNAPMP22NPSR1GFERMEN1 | |
| SCHEMBL5240544 | 0.80 | MYC (0.39) | LMNAPMP22NPSR1GFERMEN1 | |
| Hydrochloric Acid SCHEMBL5204621 | 0.79 | MYC (0.38) | LMNAPMP22NPSR1GFERMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |