Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.43 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.43 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.43 |
| ▸ | SPR | P35270 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071403 | 0.80 | GSK3B (0.52) | CYP17A1GSK3BDPP4SLC2A1SLC2A2 | |
| SCHEMBL11062025 | 0.75 | CYP17A1 (0.50) | CYP17A1GSK3BDPP4CYP1A2MAPK14 | |
| SCHEMBL1269006 | 0.74 | CYP17A1 (0.49) | CYP17A1GSK3BDPP4SPRCYP1A2 | |
| SCHEMBL840321 | 0.74 | GSK3B (0.52) | CYP17A1GSK3BDPP4SLC2A1SLC2A2 | |
| SCHEMBL3876328 | 0.74 | KDM4E (0.66) | CYP17A1GSK3BSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL29714856 | 0.73 | KDM4E (0.67) | CYP17A1GSK3BDPP4SLC2A1SLC2A2 | |
| SCHEMBL5683198 | 0.73 | KDM4E (0.67) | CYP17A1GSK3BDPP4SLC2A1SLC2A2 | |
| SCHEMBL15105514 | 0.73 | CYP17A1 (0.73) | CYP17A1CYP1A2 | |
| SCHEMBL10187548 | 0.72 | CYP17A1 (1.00) | CYP17A1GSK3BCYP1A2ALDH1A1HSD17B10 | |
| SCHEMBL32668647 | 0.72 | MAPT (0.52) | CYP17A1GSK3BDPP4SLC2A1SLC2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949648-B2 | Condensed pyrazole derivatives, process for producing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-09-27 | — | — | US | disclosed |
| US-20030187014-A1 | Condensed pyrazole derivatives, process for producing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-10-02 | — | — | US | disclosed |
| EP-1270572-A1 | CONDENSED PYRAZOLE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187014-A1 | Condensed pyrazole derivatives, process for producing the same and use thereof | PTGS1, PTGIS, IL5 | CYP17A1 477/4885GSK3B 3332/4885DPP4 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.