SCHEMBL634506

SCHEMBL634506

O=P(S)(Sc1ccccc1)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.42
CA2 P00918 2/20 0.41
CA4 P22748 2/20 0.41
CA5A P35218 2/20 0.41
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA5B Q9Y2D0 1/20 0.39
CFTR P13569 1/20 0.37
MAPT P10636 3/20 0.36
HSD17B10 Q99714 2/20 0.36
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MGLL Q99685 1/20 0.36
ALDH1A1 P00352 5/20 0.35
GAA P10253 3/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
ALPG P10696 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6827880 0.78 KCNH2 (0.47) KCNH2CA2CA4CA5ACA12
SCHEMBL6684937 0.78 KCNH2 (0.47) KCNH2CA2CA4CA5ACA12
SCHEMBL10710925 0.76 KCNH2 (0.45) KCNH2CA2CA4CA5ACA12
SCHEMBL3077639 0.74 KCNH2 (0.44) KCNH2CA2CA4CA5ACA12
SCHEMBL5351835 0.74 KCNH2 (0.44) KCNH2CA2CA4CA5ACA12
SCHEMBL3081826 0.73 ESR1 (0.37) KCNH2CA2CA4CA5ACA12
SCHEMBL6831537 0.73 CA2 (0.52) KCNH2CA2CA4CA5ACA12
SCHEMBL1883203 0.72 KCNH2 (0.61) KCNH2CA2CA4CA5ACA12
SCHEMBL4926345 0.69 CA2 (0.52) CA2CA4CA5ACFTRMAPT
SCHEMBL11174295 0.69 CA2 (0.52) CA2CA4CA5ACFTRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2025-07-22 US disclosed
CN-115175950-B Curable compositions of benzoxazine and phthalonitrile resins 亨斯迈先进材料美国有限责任公司 2025-01-28 CN disclosed
US-20230023657-A1 Phthalonitrile Resins, Methods Of Making Same And Compositions Thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2023-01-26 US disclosed
US-20220403108-A1 Curable Compositions Of Benzoxazine And Phthalonitrile Resins HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2022-12-22 US disclosed
EP-4051727-A1 PHTHALONITRILE RESINS, METHODS OF MAKING SAME AND COMPOSITIONS THEREOF Huntsman Advanced Materials Americas LLC (US) 2022-09-07 EP disclosed
EP-4051726-A1 CURABLE COMPOSITIONS OF BENZOXAZINE AND PHTHALONITRILE RESINS Huntsman Advanced Materials Americas LLC (US) 2022-09-07 EP disclosed
WO-2021087193-A1 PHTHALONITRILE RESINS, METHODS OF MAKING SAME AND COMPOSITIONS THEREOF HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) 2021-05-06 WO disclosed
WO-2021087197-A1 CURABLE COMPOSITIONS OF BENZOXAZINE AND PHTHALONITRILE RESINS HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) 2021-05-06 WO disclosed
US-8530607-B2 Aromatic ether and alkynyl containing phthalonitriles THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2013-09-10 US disclosed
US-8524750-B2 (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds GLAXO GROUP LIMITED (GB) 2013-09-03 US disclosed
US-6891014-B2 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2005-05-10 US disclosed
EP-1507816-A1 OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY (US) 2005-02-23 EP disclosed
US-20040181029-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY, THE 2004-09-16 US disclosed
US-20040181027-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof NAVY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2004-09-16 US disclosed
US-20040181028-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof NAVY, THE, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2004-09-16 US disclosed
US-6756470-B2 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY 2004-06-29 US disclosed
US-20030229198-A1 Oligomeric hydroxy arylether phthalonitiles and synthesis thereof NAVY, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF, THE 2003-12-11 US disclosed
WO-2003091312-A1 OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRSENTED BY THE SECRETARY OF THE NAVY (US) 2003-11-06 WO disclosed
WO-2003060192-A1 NON-TOXIC CORROSION-PROTECTION RINSES AND SEALS BASED ON COBALT UNIVERSITY OF DAYTON (US) 2003-07-24 WO disclosed
US-5247060-A Curing phthalonitriles with acid THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1993-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof PNN, PAH, CUL4B KCNH2 3599/4885CA2 2617/4885CA4 1442/4885
US-20230023657-A1 Phthalonitrile Resins, Methods Of Making Same And Compositions Thereof PNN, PAH, CUL4B KCNH2 3599/4885CA2 2617/4885CA4 1442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.