Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345066 | 0.89 | ALDH1A1 (0.42) | TRPM8ALDH1A1KDM4EUSP2PGR | |
| SCHEMBL6354208 | 0.87 | ALDH1A1 (0.43) | TRPM8ALDH1A1KDM4EUSP2PGR | |
| SCHEMBL6347733 | 0.87 | ALDH1A1 (0.43) | TRPM8ALDH1A1KDM4EUSP2PGR | |
| SCHEMBL6347856 | 0.87 | ALDH1A1 (0.43) | TRPM8ALDH1A1KDM4EUSP2PGR | |
| SCHEMBL6351176 | 0.82 | TRPM8 (0.44) | TRPM8ALDH1A1KDM4EUSP2PGR | |
| SCHEMBL6350978 | 0.79 | ALDH1A1 (0.45) | ALDH1A1KDM4EUSP2PGRADRA2A | |
| SCHEMBL6349361 | 0.79 | ALDH1A1 (0.45) | ALDH1A1KDM4EUSP2PGRADRA2A | |
| SCHEMBL6356051 | 0.79 | ALDH1A1 (0.45) | ALDH1A1KDM4EUSP2PGRADRA2A | |
| SCHEMBL6358138 | 0.77 | TRPM8 (0.51) | TRPM8ALDH1A1KDM4EUSP2KMT2A | |
| SCHEMBL6350920 | 0.77 | ALDH1A1 (0.41) | TRPM8ALDH1A1KDM4EUSP2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |