Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.75 |
| ▸ | RXRB | P28702 | 11/20 | 0.75 |
| ▸ | RXRG | P48443 | 11/20 | 0.75 |
| ▸ | RARG | P13631 | 9/20 | 0.75 |
| ▸ | RARB | P10826 | 8/20 | 0.75 |
| ▸ | RARA | P10276 | 6/20 | 0.75 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6347155 | 1.00 | RXRA (0.75) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6346710 | 0.90 | RXRA (0.76) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6344909 | 0.88 | RXRA (0.77) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6344906 | 0.88 | RXRA (0.77) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6337384 | 0.87 | RXRA (0.57) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6337388 | 0.87 | RXRA (0.57) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6343142 | 0.86 | RXRA (0.57) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6343138 | 0.86 | RXRA (0.57) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL11485389 | 0.86 | RXRA (1.00) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL6337614 | 0.80 | RXRA (0.62) | RXRARXRBRXRGRARGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884820-B2 | 5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity | ALLERGAN, INC. (US) | 2005-04-26 | — | — | US | disclosed |
| US-20040198825-A1 | 5,6,7,8-Tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity | ALLERGAN, INC. | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198825-A1 | 5,6,7,8-Tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity | TPO, TTR, FABP1 | RXRA 145/4885RXRB 248/4885RXRG 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.