⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10466409 | 0.97 | CYP3A4 (0.45) | — | |
| SCHEMBL58386 | 0.72 | — | — | |
| SCHEMBL3217517 | 0.67 | — | — | |
| SCHEMBL491558 | 0.67 | — | — | |
| Benzene SCHEMBL8015363 | 0.67 | TSHR (0.44) | — | |
| SCHEMBL298031 | 0.67 | — | — | |
| SCHEMBL260879 | 0.67 | — | — | |
| SCHEMBL22632969 | 0.65 | CYP3A4 (0.58) | — | |
| SCHEMBL292329 | 0.65 | — | — | |
| SCHEMBL221178 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338412-B2 | Inhibitors of P38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-25 | — | — | US | claimed |
| EP-1309560-B1 | Pyridine derivatives as inhibitors of p38 | VERTEX PHARMA (US) | 2012-10-03 | — | — | EP | claimed |
| US-20110281878-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-17 | — | — | US | claimed |
| US-20110160163-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-30 | — | — | US | claimed |
| EP-2336111-A1 | Heterocyclic inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-22 | — | — | EP | claimed |
| US-7919513-B2 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-05 | — | — | US | claimed |
| US-20090318452-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-24 | — | — | US | claimed |
| US-7598277-B2 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | claimed |
| EP-2062879-A1 | Heterocyclic inhibitors of p38 | Vertex Pharmceuticals Incorporated (US) | 2009-05-27 | — | — | EP | claimed |
| US-20090075981-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-03-19 | — | — | US | claimed |
| US-20020010170-A1 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED | 2002-01-24 | — | — | US | claimed |
| WO-2001070695-A1 | PYRIDINE DERIVATIVES AS INHIBITORS OF P38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-09-27 | — | — | WO | claimed |
| US-20010025044-A1 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED | 2001-09-27 | — | — | US | claimed |
| EP-1114039-A1 | INHIBITORS OF p38 | Vertex Pharmaceuticals Incorporated (US) | 2001-07-11 | — | — | EP | claimed |
| EP-1086085-A1 | INHIBITORS OF p38 | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | claimed |
| EP-1077943-A1 | HETEROCYCLIC INHIBITORS OF P38 | Vertex Pharmaceuticals Incorporated (US) | 2001-02-28 | — | — | EP | claimed |
| EP-0985406-B1 | Hair dye composition | GOLDWELL GMBH (DE) | 2000-12-06 | — | — | EP | claimed |
| WO-2000017175-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-30 | — | — | WO | claimed |
| WO-1999064400-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-16 | — | — | WO | claimed |
| WO-1999058502-A1 | HETEROCYCLIC INHIBITORS OF P38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-11-18 | — | — | WO | claimed |