⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11100092 | 1.00 | — | — | |
| SCHEMBL12704653 | 1.00 | — | — | |
| SCHEMBL245584 | 0.69 | — | — | |
| SCHEMBL24190367 | 0.69 | — | — | |
| SCHEMBL24831577 | 0.67 | — | — | |
| SCHEMBL24862264 | 0.61 | — | — | |
| SCHEMBL376062 | 0.51 | — | — | |
| SCHEMBL1224717 | 0.45 | — | — | |
| SCHEMBL31667872 | 0.41 | — | — | |
| Adamantane SCHEMBL8848421 | 0.38 | CYP2C9 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287361-A1 | ENGINEERED MONOAMINE OXIDASES FOR THE PREPARATION OF STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-09-14 | — | — | US | disclosed |
| US-20230287361-A1 | ENGINEERED MONOAMINE OXIDASES FOR THE PREPARATION OF STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-09-14 | — | — | US | disclosed |
| US-8859784-B2 | Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors | CODEXIS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859784-B2 | Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors | CODEXIS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8574876-B2 | Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds | CODEXIS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120289709-A1 | Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir | CODEXIS, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120244581-A1 | Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds | CODEXIS, INC. (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120244581-A1 | Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds | CODEXIS, INC. (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120130087-A1 | Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors | CODEXIS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-8178333-B2 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds | CODEXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178333-B2 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds | CODEXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110092716-A1 | DEHYDROHALOGENATION PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN PROVIDING 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS | KWOK DAW-LONG | 2011-04-21 | — | — | US | disclosed |
| US-20100063300-A1 | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | CODEXIS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
| US-20100063300-A1 | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | CODEXIS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
| WO-2010008828-A2 | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | CODEXIS, INC. (US) | 2010-01-21 | — | — | WO | disclosed |