Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | Q9HBH1 | 1/20 | 0.37 | |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970269 | 0.86 | HPGDS (0.43) | HDAC4HDAC1MMP1MMP3PLG | |
| SCHEMBL5970266 | 0.81 | HDAC4 (0.54) | HDAC4HDAC1PLGHDAC3HDAC7 | |
| SCHEMBL6350490 | 0.80 | HDAC4 (0.51) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL5971110 | 0.77 | KLKB1 (0.42) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL5970151 | 0.75 | CPA1 (0.46) | HDAC4HDAC1EHMT2MMP1MMP3 | |
| SCHEMBL5970300 | 0.75 | SIRT5 (0.52) | HDAC4HDAC1PLGHDAC3HDAC7 | |
| SCHEMBL5970942 | 0.75 | SIRT5 (0.52) | HDAC4HDAC1PLGHDAC3HDAC7 | |
| SCHEMBL5970139 | 0.75 | SIRT5 (0.55) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL5970983 | 0.75 | SIRT5 (0.55) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL5970333 | 0.74 | HDAC4 (0.45) | HDAC4HDAC1HDAC3HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849757-B2 | Antiangiogenic drug to treat cancer, arthritis and retinopathy | ABBOTT LABORATORIES (US) | 2005-02-01 | — | — | US | claimed |