Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.49 |
| ▸ | SHBG | P04278 | 2/20 | 0.49 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262886 | 1.00 | CYP19A1 (0.49) | CYP19A1LMNAGPBAR1SHBGSERPINA6 | |
| SCHEMBL6262894 | 1.00 | CYP19A1 (0.49) | CYP19A1LMNAGPBAR1SHBGSERPINA6 | |
| SCHEMBL8451508 | 0.88 | LMNA (0.51) | CYP19A1LMNAGPBAR1SHBGSERPINA6 | |
| SCHEMBL11660824 | 0.84 | GRIN2D (0.39) | CYP19A1LMNASHBGCYP1A2CYP3A4 | |
| SCHEMBL6341481 | 0.81 | AR (0.46) | CYP19A1LMNAGPBAR1SHBGSERPINA6 | |
| SCHEMBL6265622 | 0.80 | SHBG (0.41) | CYP19A1SHBG | |
| SCHEMBL6265619 | 0.80 | SHBG (0.41) | CYP19A1SHBG | |
| SCHEMBL3856204 | 0.80 | SHBG (0.41) | CYP19A1LMNAGPBAR1SHBGSERPINA6 | |
| SCHEMBL6820039 | 0.79 | GRIN1 (0.42) | CYP19A1GPBAR1CYP3A4 | |
| SCHEMBL8639699 | 0.78 | CYP17A1 (0.42) | CYP19A1SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203074-A1 | Modified aromatase inhibitors having improved bioavailability | KNELLER BRUCE W (US) | 2005-09-15 | — | — | US | claimed |