Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.36 |
| ▸ | LATS1 | O95835 | 3/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345411 | 1.00 | TP53 (0.37) | TP53ALDH1A1HSP90AA1CYP3A4THRB | |
| SCHEMBL6167497 | 0.87 | TLR8 (0.40) | CRHR1HCAR3 | |
| SCHEMBL6166421 | 0.85 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL6168054 | 0.80 | CRHR1 (0.42) | TP53ALDH1A1SMN1; SMN2CRHR1LATS1 | |
| SCHEMBL6167603 | 0.80 | CRHR1 (0.42) | TP53ALDH1A1SMN1; SMN2CRHR1LATS1 | |
| SCHEMBL6166430 | 0.79 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL6167318 | 0.78 | CYP1A2 (0.33) | ALDH1A1SMN1; SMN2HIF1ATDP1L3MBTL1 | |
| SCHEMBL6345782 | 0.77 | CRHR1 (0.49) | ALDH1A1SMN1; SMN2HSD17B10CRHR1LATS1 | |
| SCHEMBL6344899 | 0.77 | CRHR1 (0.49) | ALDH1A1SMN1; SMN2HSD17B10CRHR1LATS1 | |
| SCHEMBL6168593 | 0.76 | CRHR1 (0.46) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964965-B2 | Substituted pyrazine derivatives | PHARMACIA & UPJOHN (US) | 2005-11-15 | — | — | US | disclosed |
| US-20040053941-A1 | Substituted pyrazine derivatives | PHARMACIA & UPJOHN COMPANY | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053941-A1 | Substituted pyrazine derivatives | CRHR1, CRHR2, CRH | TP53 4754/4885ALDH1A1 749/4885HSP90AA1 2937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.